Does Caffeic Acid Phenethyl Ester improve right ventricular function and reduce arrhythmogenesis in pulmonary arterial hypertensive rats?
Caffeic Acid Phenethyl Ester (CAPE) may represent a potential therapeutic candidate for PAH-related cardiac remodeling and dysfunction by improving right ventricular function and reducing arrhythmogenesis in preclinical models.
currents, along with the expression of their corresponding channel proteins. CAPE also significantly mitigated RV remodeling induced by PA banding, a model of fixed PA stenosis. These results indicate that CAPE ameliorates structural and electromechanical abnormalities in pressure-overloaded right hearts, likely through inhibition of oxidative stress. CAPE may represent a potential therapeutic candidate in PAH-related cardiac remodeling and dysfunction. Trial Registration: NCT03049046.
Chang et al. (Mon,) studied this question.