This review highlights the mitochondria-ROS-HIF-1alpha-Kv1.5 pathway as a unifying pathophysiological mechanism and promising therapeutic target for both pulmonary arterial hypertension and cancer.
No takes yet. Share an insight, caveat, or question.
May support targeting the mitochondria-ROS-HIF-1α-Kv1.5 pathway in PAH and cancer; leaves open clinical translation of dichloroacetate.
Archer et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: