What question did this study set out to answer?

Assess autoantibody profiles and clinical presentations in juvenile systemic sclerosis patients.

April 30, 2026

P123 Autoantibody profile and clinical associations in juvenile systemic sclerosis

Key Points

Assess autoantibody profiles and clinical presentations in juvenile systemic sclerosis patients.
Analyzed 28 juvenile systemic sclerosis patients from PASTIES study.
Utilized Radio-IP and mass spectrometry for characterization of autoantibodies.
Performed statistical analysis using R version 4.5.1.
Autoantibodies detected in 25 of 28 juvenile systemic sclerosis patients (89%).
Anti-U1 positivity linked to specific clinical features and lower gastrointestinal risk.
Anti-PM-Scl associated with interstitial lung disease and overlap disease.

Abstract

Abstract Background/Aims Autoantibodies are valuable diagnostic and prognostic biomarkers in the systemic autoimmune/inflammatory disease systemic sclerosis (SSc) and associate with specific clinical phenotypes. Juvenile-onset SSc (JSSc) is very rare and studies investigating autoantibody profiles in children affected are sparse. This study aimed to assess autoantibody profiles and associated clinical presentations in JSSc patients. Methods 28 JSSc patients recruited to PAtient STratification John D Pauling has undertaken consultancy work, educational support and/or received speaker honoraria from Astra Zenaca, Boehringer Ingelheim, John & Johnson, IsoMab and CSL Vifor.. C. Hedrich: None. C.E. Pain: None. K.S. Torok: None. S.L. Tansley: None. S. Maltby: None. M. Elfadil: None.

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Cite This Study

McMorrow et al. (Wed,) studied this question.

synapsesocial.com/papers/69f2a42a8c0f03fd677632a9 https://doi.org/https://doi.org/10.1093/rheumatology/keag121.157

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