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April 30, 2026Asian Journal of AndrologyOpen Access

Predicting the upgrading of the International Society of Urological Pathology Grade Group in nonclinically significant prostate cancer: a multicenter observational study

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Authors

LZLing ZhouSir Run Run Shaw HospitalSLShiyan LiSir Run Run Shaw HospitalZWZhang-Yun WangJiangxi Provincial People's Hospital

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Implication

Observational study identifies MRI and ultrasound techniques as key predictors of ISUP Grade Group upgrading in prostate cancer biopsies.

Key Points

  • The research aims to identify predictors of ISUP Grade Group upgrading in nonclinically significant prostate cancer post-biopsy.
  • Conducted a multicenter observational study
  • Analyzed clinical data from 231 patients undergoing TRUS-guided biopsy and radical prostatectomy
  • Applied univariate and multivariate logistic regression analyses
  • Evaluated diagnostic efficiency using receiver operating characteristic curves
  • Identified magnetic resonance imaging and contrast-enhanced ultrasound as independent predictors
  • Demonstrated the highest diagnostic performance with an AUC of 0.738
  • Noted MRI showed superior predictive efficacy in smaller prostate volumes compared to CEUS

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69f2a42a8c0f03fd677633d1https://doi.org/10.4103/aja2025115
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Also Consider

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  4. 4Prostate Size as a Predictor of Gleason Score Upgrading in Patients With Low Risk Prostate Cancer2011 · 63 citations