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April 30, 2026Lara D. Veeken0 citations

Crowned Dens Syndrome with Hypoglossal Nerve Palsy and Colchicine Response: A Case Report

E057 Steroid-refractory crowned dens syndrome presenting as isolated hypoglossal nerve palsy with partial response to colchicine

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Authors

KSKriti SharmaHIH. G. IRVINEUAUrwah Ahmed

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Overview

Case report reveals hypoglossal nerve palsy in a 79-year-old, suggesting colchicine may have a delayed effect in treatment.

Key Points

  • To present a unique case of crowned dens syndrome presenting with isolated hypoglossal nerve palsy.
  • Detailed case report of clinical presentation and management.
  • Performed blood tests showing raised rheumatoid factor and imaging studies including MRI and CT.
  • Initiated treatment with oral prednisolone and colchicine.
  • MRI indicated pannus formation affecting the hypoglossal nerve leading to nerve palsy.
  • Patient showed partial response to colchicine and required multiple adjustments in treatment over 12 months.
  • Persistent symptoms and lack of improvement with steroid injections highlighted the complexity of the case.

Cite This Study

Sharma et al. (2026) studied this question.

synapsesocial.com/papers/69f2a42a8c0f03fd677633f9https://doi.org/10.1093/rheumatology/keag121.281
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