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April 30, 2026CNS Neuroscience & TherapeuticsOpen Access

Development of a Novel Prognostic Inflammation Index to Predict Poor Outcomes in Patients With Intracerebral Hemorrhage: A Longitudinal Study

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Authors

GCGuangyong ChenFCFeng ChenXLXin Lu

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Overview

Longitudinal study shows inflammation index predicts poor outcomes in intracerebral hemorrhage patients, indicating its potential clinical utility.

Key Points

  • To develop a prognostic inflammation index based on leukocyte counts to predict outcomes in intracerebral hemorrhage patients.
  • Evaluated 1021 ICH patients as the derivation cohort and 366 for internal validation.
  • Constructed the Prognostic inflammation index using reduced-rank regression analysis of leukocyte subsets.
  • Employed multivariate logistic regression to analyze associations between PII and patient outcomes.
  • Elevated PII is significantly linked to poor outcomes and all-cause mortality within one year.
  • Patients with persistently high PII have a substantially increased risk of poor outcomes.
  • Compared to traditional inflammatory markers, PII shows favorable predictive performance for ICH outcomes.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69f2a47b8c0f03fd67763751https://doi.org/10.1002/cns.70904
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Also Consider

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  1. 1ABSTRACT NUMBER: ESOC2026A57 INCREMENTAL VALUE OF INFLAMMATORY BIOMARKERS AS COMPLEMENT TO ICH SCORE IN PREDICTING INTRACEREBRAL HEMORRHAGE PROGNOSIS2026
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  4. 4The clinical value of inflammation index in predicting ICU mortality of critically ill patients with intracerebral hemorrhage2024 · 20 citations
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