Experimental findings show octreotide reduces growth and induces apoptosis in colonic cancer cells, indicating its potential impact on tumorigenesis.
Somatostatin can suppress the growth of various tumor cells including colonic cancer. Activated Wnt/β-catenin signaling pathway plays a critical role in tumorgenesis and development of colorectal cancer. However, the effect of somatostatin on Wnt/β-catenin signaling pathway remains unknown. Thus, we investigated the effect of octreotide on Wnt/β-catenin signaling pathway in human colonic cancer cell SW480. The results of 3-(4,5-imethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) and flow cytometric assays showed that octreotide inhibited growth, induced apoptosis and arrested the G1 cell cycle of SW480 cells in a dose-dependent manner. We demonstrated that octreotide significally up-regulated and down-regulated 13 genes and 17 genes in Wnt/β-catenin signaling using microarray, respectively. Furthermore, as evidenced by western blot, β-catenin protein level decreased, whereas phosphorylated β-catenin protein level increased under octreotide. The present study reveals that octreotide can inhibit human colonic cancer cell growth through inhibition of Wnt/β-catenin signaling pathway.
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Chen et al. (2009) studied this question.
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