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January 1, 2026Allergy Asthma & Respiratory DiseaseOpen Access

Cluster analysis of laryngomalacia in infants: insights into prognostic factors from a 10-year cohort

Younga Kim Jeongeun Kang Mi Sook Yun Sungsu Jung

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Key Points

This research aims to identify phenotypes of laryngomalacia and evaluate associated prognostic factors.
Retrospective review of 195 children with laryngomalacia from 2014 to 2023.
Flexible laryngoscopy or bronchoscopy used for diagnosis and data collection.
Hierarchical cluster analysis applied to ten clinical variables.
Four distinct laryngomalacia phenotypes identified through cluster analysis.
Cluster 3 showed highest surgical intervention rates at 32.5%.
Children with multiple comorbidities and feeding problems had higher hospitalization risks, with an aOR of 2.65.

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Implication

Cluster analysis reveals distinct laryngomalacia phenotypes in infants, indicating comorbidities influence hospitalizations and interventions.

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Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69f2a4b78c0f03fd67763d60 https://doi.org/10.4168/aard.2026.14.2.84

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1Anatomical subtypes and swallowing dysfunction as predictors of disease severity in pediatric laryngomalacia: a cohort studyCohort Study · 2026
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3A Retrospective Study of Outcomes of Surgical Management of Severe LaryngomalaciaCohort Study · 2026
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5Sleep-Disordered Breathing and Clinical Presentation in Infants with Congenital Laryngomalacia: A Polysomnographic Study2025 · 3 citations