What question did this study set out to answer?

To evaluate the accuracy of automated fragmented red cell counting in hemolytic anemia and the effects of microcytosis and poikilocytosis.

April 30, 2026Indian Journal of Pathology and MicrobiologyOpen Access

Automated fragmented red cell (FRC) counting in hemolytic anemia: Do poikilocytes and microcytes interfere?

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Authors

BRBR RajalakshmiJSS Academy of Higher Education and Research SKShelby P. KunjukunjuJSS Academy of Higher Education and Research SSS SuchithaJSS Academy of Higher Education and Research

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Implication

Automated FRC counting reveals accurate measurement of schistocytes in hemolytic anemia, suggesting microcytic hypochromic anemia may complicate results.

Key Points

To evaluate the accuracy of automated fragmented red cell counting in hemolytic anemia and the effects of microcytosis and poikilocytosis.
Analyzed cases of extravascular hemolysis, intravascular hemolysis, and microcytic hypochromic anemia.
Used Mindray BC-6200 analyzer for automated FRC% and related indices.
Compared manual FRC count with automated FRC% across groups.
High agreement between manual and automated FRC% in intravascular hemolysis (96.6% sensitivity, 100% specificity).
Anisopoikilocytosis showed a strong correlation with FRC% in extravascular hemolysis (r = 0.812).
Microcytosis correlated moderately with FRC% in microcytic hypochromic anemia (MHA) but not in others.

Cite This Study

Rajalakshmi et al. (2026) studied this question.

synapsesocial.com/papers/69f2a4da8c0f03fd67763e42 https://doi.org/10.4103/ijpm.ijpm_912_25

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Implication

Automated FRC counting reveals accurate measurement of schistocytes in hemolytic anemia, suggesting microcytic hypochromic anemia may complicate results.

Automated fragmented red cell (FRC) counting in hemolytic anemia: Do poikilocytes and microcytes interfere?

Discussion

Member takes

Implication

Key Points

Cite This Study

Automated fragmented red cell (FRC) counting in hemolytic anemia: Do poikilocytes and microcytes interfere?

Discussion

Member takes

Implication

Key Points

Cite This Study

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