Experiments demonstrate ATSE reduces cell death and neurotoxicity in PC12 cells, suggesting benefits for Alzheimer's disease.
Amyloid-β induced neurotoxicity has been identified as a major cause of Alzheimer's disease. Acorus tatarinowii Schott is one of the most frequently used Chinese herbs for Alzheimer's disease treatment. However, the effects of Acorus tatarinowii Schott on amyloid-β mediated nerve cell damage remains unknown. In the present study, neuronal differentiated PC12 cells were used as a model to evaluate the effects of A. tatarinowii Schott extract (ATSE) against Aβ25–35 induced neurotoxicity. The results showed pretreatment with ATSE significantly protected PC12 cells from Aβ25–35 induced cell death, lactate dehydrogenase release, DNA damage, mitochondrial dysfunction and cytochrome c release from mitochondria. In addition, pretreatment with ATSE also significantly inhibited Aβ25–35 induced caspase-3 activation and reactive oxygen species generation in PC12 cells. These observations suggested that ATSE protects PC12 cells from amyloid-induced neurotoxicity.
No takes yet. Share an insight, caveat, or question.
An et al. (2014) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: