Why the study?
Does the electro-mechanical window (EMw) predict the occurrence of Torsade de Pointes in a canine model of drug-induced arrhythmias?
Does the electro-mechanical window (EMw) predict the occurrence of Torsade de Pointes in a canine model of drug-induced arrhythmias?
The electro-mechanical window may serve as a risk marker for Torsade de Pointes independent of QT prolongation in preclinical models.
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Negative EMw signals TdP risk in this canine model; hypothesis-generating for EMw as QT-independent marker in preclinical studies.
Linde et al. (2010) studied this question.
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