materials. Apart from high efficiencies, HP-MOFS exhibited excellent stability in solvents commonly used in column packing and mobile phase preparation, and what's more, maintained a good structural integrity under high operating pressures up to 40 MPa. These findings indicate that HP-MOFS, as a synergetic combination of spherical morphology and hierarchically porous architecture, can effectively improve the performance of MOFs in liquid phase separations. From a precision manufacturing standpoint, the results suggest that it is the pore design and morphology control that play the central role in developing high performance MOF chromatography.
Li et al. (2026) studied this question.