July 1, 2001Journal of Biological ChemistryOpen Access

Platelet Activation by von Willebrand Factor Requires Coordinated Signaling through Thromboxane A2 and FcγIIA Receptor

View Full Paper

Ask AI

Bookmark

Population

Human and mouse platelets

Comparison

von Willebrand Factor stimulation in the… vs Thrombin stimulation or unstimulated controls

Design

Preclinical

Authors

ICIlaria CanobbioLombardia Informatica (Italy)ABAlessandra BertoniUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”PLPaolo LovaUniversity of Pavia

Discussion

Member takes

Implication

Hypothesis-generating for PLC gamma 2 targeting in vWF thrombosis; requires human validation before any clinical consideration.

Structured PICO

Population

Human and mouse platelets

Intervention

von Willebrand Factor (vWF) stimulation in the presence or absence of inhibitors (anti-Fc gamma RIIA monoclonal antibody IV.3, acetylsalicylic acid, piceatannol, wortmannin)

Comparator

Thrombin stimulation or unstimulated controls

Outcome

Platelet activation (pleckstrin phosphorylation, serotonin secretion, tyrosine phosphorylation of Fc gamma RIIA, Syk, and PLC gamma 2)surrogate

This study elucidates the signaling pathway of vWF-induced platelet activation, highlighting the essential coordinated roles of TxA2 and the Fc gamma RIIA receptor in activating PLC gamma 2.

Cite This Study

Canobbio et al. (2001) studied this question.

synapsesocial.com/papers/69f2f0c2e4cdef8ca70fcb01 https://doi.org/10.1074/jbc.m102639200

View Full Paper

Ask AI

Bookmark

Platelet Activation by von Willebrand Factor Requires Coordinated Signaling through Thromboxane A2 and FcγIIA Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Platelet Activation by von Willebrand Factor Requires Coordinated Signaling through Thromboxane A2 and FcγIIA Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider