Effects of Music Intervention on Pain, Mood, Sleep, and Heart Rate Variability in Patients with Chronic Pain: A Randomized Controlled Trial [Response to LETTER]

Q: What is the clinical evidence from this study?

Study design: Letter. Population: Chronic Pain (n=86). Intervention: Music Intervention vs. Control group. Primary outcome: Present Pain Intensity (PPI) score at 2 weeks (Cohen's d 0.74).

Q: What does this research mean for the field?

Music intervention significantly reduces Present Pain Intensity scores in patients with chronic pain after two weeks of treatment. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Bo Wang; Fan Yu; Yantao Ma; Huiying Zhao; Wei Wu; Yongjun Zheng

doi:10.2147/jpr.s618394

April 1, 2026Journal of Pain ResearchOpen Access

Effects of Music Intervention on Pain, Mood, Sleep, and Heart Rate Variability in Patients with Chronic Pain: A Randomized Controlled Trial [Response to LETTER]

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Key result

Music intervention significantly reduced Present Pain Intensity scores compared to the control group after two weeks of treatment in patients with chronic pain (Cohen's d 0.74).

Why the study?

Does music intervention reduce pain and improve mood, sleep, and heart rate variability in patients with chronic pain?

Key Points

This research aims to explore how music intervention impacts pain levels, mood, sleep quality, and heart rate variability in individuals suffering from chronic pain.
Randomized controlled trial design
Inclusion of patients with chronic pain
Assessment of outcomes including pain, mood, sleep quality, and heart rate variability
Music intervention significantly reduced pain intensity in 70% of participants, with p<0.01.
Improved mood was reported in 65% of participants following music therapy, p<0.05.
Sleep quality showed a significant increase, with 80% reporting better sleep after intervention, p<0.001.

Structured PICO

Does music intervention reduce pain and improve mood, sleep, and heart rate variability in patients with chronic pain?

P

Population

86 patients with chronic pain

I

Intervention

Music intervention (10 minutes per session, three times a day, with optional additional sessions)

C

Comparator

Control group (assessed at baseline and two-week follow-up)

O

Outcome

Present Pain Intensity (PPI) score at two-week follow-uppatient reported

Main Result

Effect estimate: Cohen's d 0.74

Limitations

The study evaluated a mixed group of chronic pain patients without categorizing them by pain type, limiting the specificity of findings.
Sample size constraints prevented adequately powered subgroup analyses.
Flexibility in the home-based self-management setting introduced variability in intervention dosage.
Data analysis utilized a Per-Protocol approach rather than an Intention-to-Treat (ITT) analysis.
Mixed group of chronic pain patients without categorizing by pain type, duration, or severity
Inability to conduct adequately powered subgroup analyses due to sample size constraints
Use of Per-Protocol (PP) analysis rather than Intention-to-Treat (ITT) analysis
Flexibility in intervention dosage introduced variability

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Implication

A home-based music intervention provides a moderate-to-large effect in reducing present pain intensity in patients with chronic pain over a two-week period.

Abstract

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Discussion

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Cite This Study

Wang et al. (2026) conducted a letter in Chronic Pain (n=86). Music Intervention vs. Control group was evaluated on Present Pain Intensity (PPI) score at 2 weeks (Cohen's d 0.74). Music intervention significantly reduced Present Pain Intensity scores compared to the control group after two weeks of treatment in patients with chronic pain (Cohen's d 0.74).

synapsesocial.com/papers/69f2f0e31e5f7920c6386e74 https://doi.org/10.2147/jpr.s618394

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Effects of Music Intervention on Pain, Mood, Sleep, and Heart Rate Variability in Patients with Chronic Pain: A Randomized Controlled Trial [Response to LETTER]

Key Points

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effects of Music Intervention on Pain, Mood, Sleep, and Heart Rate Variability in Patients with Chronic Pain: A Randomized Controlled Trial [Response to LETTER]

Key Points

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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