What question did this study set out to answer?

To investigate how the volumes of the substantia nigra and locus coeruleus influence symptoms post-deep brain stimulation in advanced Parkinson's disease.

April 30, 2026Internal Medicine0 citationsOpen Access

The Predictive Value of the Substantia Nigra and Locus Coeruleus Volumes Using 3D Neuromelanin-sensitive MRI to Predict the Outcomes after Deep Brain Stimulation in Advanced Parkinson's Disease: An Exploratory Study

AHAi HanawaMie University KMKeita MatsuuraMie University HKHiroyuki KajikawaMie University

Key Points

To investigate how the volumes of the substantia nigra and locus coeruleus influence symptoms post-deep brain stimulation in advanced Parkinson's disease.
Exploratory study utilizing 3D neuromelanin-sensitive MRI for volume measurement.
Focused on motor and non-motor symptoms following deep brain stimulation.
Sample included patients diagnosed with advanced Parkinson's disease.
Significant correlation between substantia nigra and locus coeruleus volumes and symptom outcomes post-DBS.
Findings indicate the potential of these brain volumes as predictive biomarkers for therapy response.
Results support the use of advanced imaging techniques in neurodegenerative disease assessment.

Abstract

Purpose: To explore the relationship between the substantia nigra and the locus coeruleus volumes (SNV and LCV, respectively) measured with 3D neuromelanin-sensitive magnetic resonance imaging (NMI) and motor/non-motor symptoms after deep brain stimulation (DBS) in patients with advanced Parkinson's disease (PD).

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