An SPP1-SOCS1 pathway constrains interferon responses in tumor-associated macrophages and shapes an immunosuppressive tumor microenvironment

Key Points

• This research aims to explore how the SPP1-SOCS1 pathway affects interferon responses in tumor-associated macrophages.
• Examined the SPP1-SOCS1 pathway in tumor-associated macrophages.
• Analyzed the impact on interferon signaling and overall tumor microenvironment.
• Utilized in vitro and in vivo models to assess macrophage behavior.
• The SPP1-SOCS1 pathway significantly reduced interferon responses in tumor-associated macrophages.
• Enhanced immunosuppressive characteristics of the tumor microenvironment were observed due to pathway activation.
• Blocking the SPP1-SOCS1 pathway led to increased interferon sensitivity in macrophages.