Investigates a method for synthesizing azetidines, indicating practical applications in pharmaceuticals.
), and (iv) the kinetic study of the developed methodology. The strategy exhibits broad substrate scope and scalability, making it practical. Installation of generated azetidines into marketed drug motifs, including ibuprofen, naproxen, and olaparib derivative, demonstrates the method's utility. Mechanistic investigations, supported by control experiments, cyclic voltammetry, and electrochemical impedance spectroscopy (EIS), provided key insights into the reaction pathway. This electrochemical approach advances the strain-release chemistry of ABBs and offers a promising platform for future developments.
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Duhan et al. (2026) studied this question.
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