Key result
The PTEN-PI3K-Akt-mTOR signaling pathway provides useful curative targets for managing heart failure and cardiac hypertrophy.
Why the study?
Targeted regulation of the PTEN gene in signal transduction pathways forms the basis for developing new PTEN-modifying therapies for chronic heart failure and related cardiovascular diseases.
Modulation of the PTEN signaling pathway offers a potential therapeutic target for treating cardiac hypertrophy and chronic heart failure.
Caution advised against PTEN targeting in HF care; leaves open its differential role in physiological versus pathological hypertrophy for dedicated trials.
This review focuses on the current and past state of understanding with regards to the function of PTEN gene in signalling pathways in chronic heart failure and cardiac hypertrophy and explores how PTEN signalling is modified in the same. The role of PTEN in both pathological and physiological cardiac hypertrophy and how regulation and dysregulation contribute to chronic heart failures and cardiac hypertrophy are also discussed. The modulation of transduction pathway by PTEN with regards to cardiac remodelling, hypertrophy, phenotypic modulation, and apoptosis in both healthy and hypertrophic hearts are talked over. Targeted regulation of PTEN gene in signal transduction pathway forms the basis of development of new PTEN modifying therapies for use in chronic heart failures and related cardiovascular diseases. Signalling pathways are implicated in both pathological and physiological cardiac hypertrophy. These signals involve various protein kinases and activation or inactivation of specific genes that have a role in cardiomyocyte proliferation and apoptosis.
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Agbo et al. (2018) conducted a review in Cardiac hypertrophy and chronic heart failure. PTEN gene regulation was evaluated. The PTEN-PI3K-Akt-mTOR signalling pathway comprises useful curative targets for the clinical management of heart failure and cardiac hypertrophy.
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