Evaluates MCCII's effectiveness in enhancing drug release in pellets, indicating its potential as a pelletization aid.
Microcrystalline cellulose II (MCCII) is a different allomorph of MCC that can be used as a filler and a disintegrant for direct compression. MCCII was studied as new pelletization aid with the aim to prepare pellets with a faster drug release than MCCI-based pellets. MCCII-based pellets showed an immediate diphenydramine. HCl release profile comparable to that of Benadryl® and a faster griseofulvin release than MCCI-based pellets. MCCII offers potential to use as an alternative pelletization aid.
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Rojas et al. (2012) studied this question.
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