Bioavailability of 6′-Sialyllactose and 3′-Sialyllactose: Dynamic Interplay between Intestinal Absorption and Microbial Metabolism as a Main Driver

Li X; Zhang Y; Fupei Xu; Xuemeng Ji; Yì Wáng; Che Pan; Yingyi Mao; Poh Leong Chiang; Li X; Y Q Hu; Huan Lv; Dancai Fan; Bowei Zhang; Shuo Wang

doi:10.1021/acs.jafc.5c13148

April 27, 2026Journal of Agricultural and Food Chemistry

Bioavailability of 6′-Sialyllactose and 3′-Sialyllactose: Dynamic Interplay between Intestinal Absorption and Microbial Metabolism as a Main Driver

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Key Points

This research examines how the gastrointestinal absorption of sialyllactoses impacts their bioavailability and metabolism.
Investigated hydrolysis rates of 6'-sialyllactose and 3'-sialyllactose.
Analyzed the primary metabolites produced during fermentation in the gut.
Assessed effects on brain bioavailability through absorption dynamics.
6'-Sialyllactose demonstrated a lower hydrolysis rate compared to 3'-sialyllactose.
The slower hydrolysis of 6'-sialyllactose may enhance the brain availability of sialic acid (SA).
Reduced excretion rates contributed to increased retention of sialyllactoses in the body.

Implication

Investigates how intestinal absorption affects the bioavailability of sialyllactoses, suggesting implications for brain health.

Abstract

fermentation, SA was the primary metabolite of SLs. The hydrolysis rate of 6'-SL was lower than 3'-SL, suggesting that 6'-SL may increase the brain bioavailability of its active form, SA, via slow hydrolysis and absorption as well as reduced excretion.

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Cite This Study

X et al. (2026) studied this question.

synapsesocial.com/papers/69f2f1be1e5f7920c6387645 https://doi.org/10.1021/acs.jafc.5c13148

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Bioavailability of 6′-Sialyllactose and 3′-Sialyllactose: Dynamic Interplay between Intestinal Absorption and Microbial Metabolism as a Main Driver

Key Points

Implication

Abstract

Discussion

Cite This Study

Bioavailability of 6′-Sialyllactose and 3′-Sialyllactose: Dynamic Interplay between Intestinal Absorption and Microbial Metabolism as a Main Driver

Key Points

Implication

Abstract

Discussion

Cite This Study

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