What question did this study set out to answer?

To evaluate the effects of L-NAME on ECG intervals in individuals with tetraplegia and controls.

April 30, 2026Die PharmazieOpen Access

Acute nitric oxide synthase inhibition and cardiac conduction in persons with spinal cord injury: a short report

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Short report assessing cardiac conduction effects of L-NAME on spinal cord injury and control subjects, suggesting no adverse impact.

To evaluate the effects of L-NAME on ECG intervals in individuals with tetraplegia and controls.
Open-label trial administering intravenous L-NAME at 0, 1, 2, or 4 mg·kg–1 in supine position
Conducted orthostatic challenge in SCI group with L-NAME doses of 0, 1, or 2 mg·kg–1
ECGs were recorded at baseline and at specified time intervals after L-NAME administration.
No significant changes in ECG intervals were observed across doses in either group
L-NAME did not induce hypertensive crises during the study
Twelve subjects experienced no statistical differences in ECG measures between groups at baseline.

Fountaine et al. (2013) studied this question.

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