November 12, 2012Proceedings of the National Academy of SciencesOpen Access

Atypical angiopoietin-like protein that regulates ANGPTL3

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Why the study?

Does ANGPTL8 regulate ANGPTL3 and lipid metabolism in mice and humans?

Population

Mice (wild-type and Angptl3(-/-)), cultured hepatocytes, and three human populations

Comparison

Expression of ANGPTL8 vs Expression of ANGPTL3 alone, and Angptl3(-/-) mice

Design

Preclinical

Authors

FQFabiana QuagliariniDeutsches Diabetes-Zentrum e.V.YWYan WangSouth China Agricultural University JKJulia KozlitinaThe University of Texas Southwestern Medical Center

Discussion

Member takes

Implication

Hypothesis-generating for ANGPTL8 as lipid target; leaves open human translation and clinical outcomes.

Structured PICO

Does ANGPTL8 regulate ANGPTL3 and lipid metabolism in mice and humans?

Population

Mice (wild-type and Angptl3(-/-)), cultured hepatocytes, and three human populations

Intervention

Expression of ANGPTL8 (alone or coexpressed with ANGPTL3)

Comparator

Expression of ANGPTL3 alone, and Angptl3(-/-) mice

Outcome

Plasma triglyceride (TAG), LDL-C, and HDL-C levelssurrogate

ANGPTL8 regulates postprandial triglyceride and fatty acid metabolism by activating ANGPTL3, identifying it as a potential therapeutic target for lipid lowering.

Cite This Study

Quagliarini et al. (2012) studied this question.

synapsesocial.com/papers/69f2f203b5d1bfa3da4198c7 https://doi.org/10.1073/pnas.1217552109

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Atypical angiopoietin-like protein that regulates ANGPTL3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Atypical angiopoietin-like protein that regulates ANGPTL3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider