Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene

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Population

Wild-type mice, PPARalpha null mice, and PPARgamma +/- mice

Comparison

Fasting and chronic high fat feeding vs Wild-type controls and non-fasting state

Design

Preclinical

Authors

Discussion

FIAF merits study as a fasting-responsive endocrine signal; leaves open its role in human metabolic disease.

Population

Wild-type mice, PPARalpha null mice, and PPARgamma +/- mice

Intervention

Fasting and chronic high fat feeding

Comparator

Wild-type controls and non-fasting state

Outcome

Identification and characterization of unknown PPARalpha target genes (specifically FIAF expression and protein levels)surrogate

Identifies FIAF as a novel PPARalpha-regulated endocrine signal involved in the metabolic response to fasting.

Kersten et al. (2000) studied this question.

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