Why the study?
Does isometric hand-grip exercise alter the myocardial phosphocreatine to ATP ratio measured by 31P NMR in patients with coronary artery disease compared to normal subjects?
Population
36 subjects, including normal subjects, patients with nonischemic heart disease, and patients with coronary…
Comparison
Isometric hand-grip exercise with spatially… vs Resting state and normal/nonischemic control…
Design
Cross-sectional
Authors
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31P NMR during exercise may detect metabolic ischemia in CAD; leaves open clinical utility pending prospective validation.
Does isometric hand-grip exercise alter the myocardial phosphocreatine to ATP ratio measured by 31P NMR in patients with coronary artery disease compared to normal subjects?
31P NMR spectroscopy can detect transient ischemic metabolic changes, specifically a decreased phosphocreatine to ATP ratio, during isometric exercise in patients with severe coronary artery disease.
Weiss et al. (1990) studied this question.
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