April 30, 2026Journal of the American College of Cardiology163 citations
View Full PaperVascular Inflammation in Subclinical Atherosclerosis Detected by Hybrid PET/MRI
Structured PICO
Does hybrid PET/MRI detect vascular inflammation in middle-aged individuals with known subclinical atherosclerosis?
P
Population
Middle-aged individuals with known subclinical atherosclerosis
I
Intervention
Large-scale multiterritorial hybrid PET/MRI
O
Outcome
Presence of arterial inflammation and plaques in carotid, aortic, and ilio-femoral territoriessurrogate
Hybrid PET/MRI demonstrates that arterial inflammation is highly prevalent in middle-aged individuals with known subclinical atherosclerosis.
Abstract
BACKGROUND: Atherosclerosis is a chronic inflammatory disease, but data on arterial inflammation at early stages is limited. OBJECTIVES: The purpose of this study was to characterize vascular inflammation by hybrid METHODS: Carotid, aortic, and ilio-femoral RESULTS: Arterial inflammation was present in 48.2% of individuals (24.4% femorals, 19.3% aorta, 15.8% carotids, and 9.3% iliacs) and plaques in 90.1% (73.9% femorals, 55.8% iliacs, and 53.1% carotids). CONCLUSIONS: Arterial inflammation is highly prevalent in middle-aged individuals with known subclinical atherosclerosis. Large-scale multiterritorial PET/MRI allows characterization of atherosclerosis-related arterial inflammation and demonstrates