What question did this study set out to answer?

To determine whether arterial 18F-FDG uptake and large-vessel calcifications detected on PET/CT can predict subsequent vascular events in asymptomatic cancer patients.

September 16, 2009Journal of Nuclear MedicineOpen Access

¹⁸F-FDG PET/CT Identifies Patients at Risk for Future Vascular Events in an Otherwise Asymptomatic Cohort with Neoplastic Disease

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Authors

ARAxel RomingerChonnam National University TSTobias SaamCardiac Imaging SWSarah WolpersLudwig-Maximilians-Universität München

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Implication

Cohort study reveals arterial 18F-FDG uptake predicts future vascular events in cancer patients, indicating metabolic vascular imaging improves cardiovascular risk stratification.

Key Points

To determine whether arterial 18F-FDG uptake and large-vessel calcifications detected on PET/CT can predict subsequent vascular events in asymptomatic cancer patients.
Analyzed clinical follow-up data from 932 cancer patients undergoing whole-body 18F-FDG PET/CT with a median follow-up of 29 months.
Quantified arterial target-to-background ratio (TBR) and calcified plaque sum scores in the ascending, descending, and abdominal aorta, aortic arch, and iliac and carotid arteries.
Vascular events (ischemic stroke, myocardial infarction, or revascularization) occurred in 15 of 932 patients (1.6%) during follow-up.
Mean arterial TBR correlated significantly with calcified plaque sum (P < 0.001) as well as age, male sex, and hypertension.
Multivariate Cox regression identified mean TBR ≥ 1.7 and calcified plaque sum ≥ 15 as independent predictors of future vascular events, with TBR demonstrating greater prognostic value.

Cite This Study

Rominger et al. (2009) studied this question.

synapsesocial.com/papers/69f3ee95dc238f8197799894 https://doi.org/10.2967/jnumed.109.065151

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Implication

Cohort study reveals arterial 18F-FDG uptake predicts future vascular events in cancer patients, indicating metabolic vascular imaging improves cardiovascular risk stratification.

¹⁸F-FDG PET/CT Identifies Patients at Risk for Future Vascular Events in an Otherwise Asymptomatic Cohort with Neoplastic Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

¹⁸F-FDG PET/CT Identifies Patients at Risk for Future Vascular Events in an Otherwise Asymptomatic Cohort with Neoplastic Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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