December 22, 2009HypertensionOpen Access

LIM and Cysteine-Rich Domains 1 Regulates Cardiac Hypertrophy by Targeting Calcineurin/Nuclear Factor of Activated T Cells Signaling

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Population

Primary cultured cardiac myocytes, cardiac-specific Lmcd1 transgenic mice, and wild-type mice subjected to…

Comparison

Lmcd1 overexpression or downregulation vs Wild-type mice or control cells

Design

Preclinical

Follow-up

8 weeks

Authors

ZBZhou‐Yan BianWuhan University HHHe HuangHeart Rhythm Society HJHong JiangPeking University

Discussion

Member takes

Implication

Lmcd1 may modulate pressure-overload remodeling via calcineurin/NFAT; hypothesis-generating in animals and leaves open human translation.

Structured PICO

Population

Primary cultured cardiac myocytes, cardiac-specific Lmcd1 transgenic mice, and wild-type mice subjected to aortic banding

Intervention

Lmcd1 overexpression (transgenic mice) or downregulation (in vitro)

Comparator

Wild-type mice or control cells

Outcome

Cardiac hypertrophy (measured by heart weight:body weight ratio, cardiomyocyte area, echocardiographic measurements, ANP/BNP levels) and calcineurin/NFAT signaling activationsurrogate

Lmcd1 plays a critical role in the development of cardiac hypertrophy via activation of the calcineurin/NFAT signaling pathway.

Cite This Study

Bian et al. (2009) studied this question.

synapsesocial.com/papers/69f3ee41dc238f81977996bd https://doi.org/10.1161/hypertensionaha.109.135665

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LIM and Cysteine-Rich Domains 1 Regulates Cardiac Hypertrophy by Targeting Calcineurin/Nuclear Factor of Activated T Cells Signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

LIM and Cysteine-Rich Domains 1 Regulates Cardiac Hypertrophy by Targeting Calcineurin/Nuclear Factor of Activated T Cells Signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider