February 29, 2004Cardiovascular Research
Calcineurin?NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs
Population
Genetically altered mice and cultured cardiomyocytes (as discussed in the review)
Design
Review
Authors
Discussion
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Member takes
Implication
No immediate clinical implications for hypertrophy; leaves open dual pathway targeting for future therapeutic validation.
Structured PICO
P
Population
Genetically altered mice and cultured cardiomyocytes (as discussed in the review)
I
Intervention
Modulation of calcineurin-NFAT and MAPK signaling pathways
O
Outcome
Cardiac hypertrophic response
Calcineurin-NFAT and MAPK signaling pathways are inter-dependent co-regulators of the cardiac hypertrophic response.
Cite This Study
Jeffery D. Molkentin (2004) studied this question.