Effect of atrial septal defect repair on left ventricular geometry and degree of mitral valve prolapse.
Why the study?
Does surgical closure of atrial septal defect improve left ventricular geometry and reduce the degree of mitral valve prolapse in patients with atrial septal defect?
Population
14 patients with atrial septal defect (50% with preoperative mitral valve prolapse)
Comparison
Surgical closure of atrial septal defect vs Preoperative baseline (self-controlled)
Design
Cohort
Follow-up
7 days postoperatively
Authors
Discussion
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Member takes
Implication
Supports hypothesis of rapid geometric improvement post-ASD closure; leaves open whether this translates to clinical benefit in randomized settings.
Structured PICO
Does surgical closure of atrial septal defect improve left ventricular geometry and reduce the degree of mitral valve prolapse in patients with atrial septal defect?
P
Population
14 patients with atrial septal defect (50% with preoperative mitral valve prolapse)
I
Intervention
Surgical closure of atrial septal defect
C
Comparator
Preoperative baseline (self-controlled)
O
Outcome
Left ventricular geometry (eccentricity) and degree of mitral valve prolapse (measured by net algebraic area subtended by apposed mitral valve leaflets in systole [MVAS])surrogate
Surgical closure of atrial septal defect rapidly normalizes left ventricular geometry and significantly reduces the degree of mitral valve prolapse within 7 days postoperatively.
Cite This Study
Schreiber et al. (1980) studied this question.