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AIMS/HYPOTHESIS: ; (2) a structural model for the interaction of SGLT2i to NHE; (3) to what extent SGLT2i affect the haemodynamic and metabolic performance of isolated hearts of healthy mice. METHODS: consumption and energetics (phosphocreatine (PCr)/ATP) were determined. EMPA and CANA, but not DAPA, induced coronary vasodilation of the intact heart. PCr/ATP remained unaffected. CONCLUSIONS/INTERPRETATION: that is known to occur in heart failure and diabetes.
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Uthman et al. (2017) studied this question.
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