What question did this study set out to answer?

To assess peripheral blood T-cell receptor repertoire diversity and evaluate its correlation with mortality and secondary infections in septic shock patients.

December 6, 2012Critical Care MedicineOpen Access

Decreased T-Cell Repertoire Diversity in Sepsis

View Full Paper

Ask AI

Bookmark

Authors

FVFabienne VenetUniversité Claude Bernard Lyon 1 OFOrchidée Filipe‐SantosDélégation Paris 5 ALAlain LepapeUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Prospective observational study reveals reduced T-cell receptor diversity in septic shock patients, indicating its link to increased mortality and nosocomial infections.

Key Points

To assess peripheral blood T-cell receptor repertoire diversity and evaluate its correlation with mortality and secondary infections in septic shock patients.
Conducted a preliminary prospective observational study in adult intensive care units at a university hospital with 41 patients with septic shock (n = 41).
Collected paired peripheral blood samples early after shock onset (day 1) and at day 7 to measure combinatorial diversity of the human T-cell receptor β-chain (TRB locus) using a molecular biology technique.
Patients presented with markedly reduced T-cell receptor diversity on day 1 followed by a steep recovery toward normal levels by day 7 (p < 0.0001, Wilcoxon's paired test).
Decreased T-cell receptor diversity was significantly associated with higher mortality (HR = 4.48; 95% CI, 1.96–53.32; p = 0.0058) and the development of nosocomial infections (p < 0.05, Mann-Whitney U test).

Cite This Study

Venet et al. (2012) studied this question.

synapsesocial.com/papers/69f3eefdfeabb348fb71d185 https://doi.org/10.1097/ccm.0b013e3182657948

View Full Paper

Ask AI

Bookmark

Implication

Prospective observational study reveals reduced T-cell receptor diversity in septic shock patients, indicating its link to increased mortality and nosocomial infections.

Decreased T-Cell Repertoire Diversity in Sepsis

Discussion

Member takes

Implication

Key Points

Cite This Study

Decreased T-Cell Repertoire Diversity in Sepsis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider