Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Among Apparently Healthy Women
Why the study?
Does elevated baseline C-reactive protein predict the risk of future cardiovascular events in apparently healthy women?
Population
366 apparently healthy women from the Women's Health Study.
Comparison
Highest baseline C-reactive protein (CRP) levels vs Lower baseline C-reactive protein (CRP) levels
Design
Case-control
Follow-up
3 years
Authors
Discussion
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Member takes
Implication
Elevated CRP was associated with higher vascular risk in healthy women; leaves open its value for risk stratification pending prospective validation.
Structured PICO
Does elevated baseline C-reactive protein predict the risk of future cardiovascular events in apparently healthy women?
P
Population
366 apparently healthy women from the Women's Health Study (122 who subsequently suffered a first cardiovascular event and 244 age- and smoking-matched control subjects who remained free of cardiovascular disease).
I
Intervention
Highest baseline C-reactive protein (CRP) levels
C
Comparator
Lower baseline C-reactive protein (CRP) levels
O
Outcome
First cardiovascular event (any vascular event, myocardial infarction, or stroke) during a 3-year follow-up periodhard clinical
Elevated baseline C-reactive protein is a strong, independent predictor of future cardiovascular events, including myocardial infarction and stroke, in apparently healthy women.
Cite This Study
Ridker et al. (1998) studied this question.