What question did this study set out to answer?

The aim is to understand thrombin generation and its various functions during tissue factor-induced coagulation.

July 1, 2002BloodOpen Access

Thrombin functions during tissue factor–induced blood coagulation

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Randomized trial evaluates thrombin generation during blood coagulation, suggesting implications for clotting disorders.

The aim is to understand thrombin generation and its various functions during tissue factor-induced coagulation.
Contact pathway-inhibited whole blood was analyzed over 54 months in 20 individuals at 37 degrees C.
Inhibitors were used to quench reactions, and soluble phases were examined for thrombin and other substrates.
Thrombin generation rates and related substrate activation phases were determined.
Initiation phase thrombin generation rate was 0.93 nM/min up to 4.6 minutes, with approximately 26 nM thrombin formed.
Propagation phase showed a rapid generation rate of 83.9 nM/min, reaching levels of 851 nM.
Clot time averaged 4.7 minutes, indicating correlation with the beginning of the propagation phase.

Brummel et al. (2002) studied this question.

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