Reveals reduced cytotoxicity of gut microbial metabolites of methoxsalen against melanoma cells, indicating metabolic modulation of coumarin bioactivities.
. Finally, gut microbial metabolites of methoxsalen had diminished cytotoxicity against melanoma cancer cells compared to the parent drug. In summary, the human gut microbiome utilizes a single metabolic pathway to modulate the bioactivities of many coumarins.
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Mingolelli et al. (2026) studied this question.
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