Bone-strengthening activity of pinocembrin in vitro and in vivo

Ayaka Tsuchiya; Maki Suzuki; Reiko Murakami; Kazuki Nakajima; Tohru Mitsunaga; Kosei Yamauchi

doi:10.1080/14786419.2026.2663514

April 28, 2026Natural Product Research

Bone-strengthening activity of pinocembrin in vitro and in vivo

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Key Points

The central aim is to evaluate the bone-strengthening effects of pinocembrin through various cellular mechanisms.
Assessing the impact of pinocembrin on bone cells in vitro and in vivo.
Investigating the roles of cell adhesion and motility factors in the effectiveness of pinocembrin.
Analyzing the inhibition of osteoclastogenesis as a pathway for strengthening bone.
Pinocembrin significantly inhibited osteoclastogenesis compared to control conditions.
Enhanced bone strength was observed both in vitro and in vivo models exposed to pinocembrin.
Interactions with integrins were identified as a key mechanism for bone strengthening.

Implication

In Vitro and In Vivo Analysis Reveals Pinocembrin Strengthens Bone by Inhibiting Osteoclast Formation, Suggesting Therapeutic Potential.

Abstract

integrins, but not actin polymerisation. Pinocembrin strengthened bone by interacting with cell adhesion and cell motility factors, and inhibiting osteoclastogenesis.

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Cite This Study

Tsuchiya et al. (2026) studied this question.

synapsesocial.com/papers/69f4427a967e944ac5565fc8 https://doi.org/10.1080/14786419.2026.2663514

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Bone-strengthening activity of pinocembrin in vitro and in vivo

Key Points

Implication

Abstract

Discussion

Cite This Study

Bone-strengthening activity of pinocembrin in vitro and in vivo

Key Points

Implication

Abstract

Discussion

Cite This Study

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