Key result
Pinocembrin improves LVEF by ~11% and reduces cardiac remodeling in a post-MI rat model.
Why the study?
Oxidative stress contributes to heart failure progression, but whether pinocembrin ameliorates post-infarct heart failure and its underlying mechanisms remained unclear.
Absolute Event Rate: 54.91% vs 43.83%
p-value: p=<0.01
Pinocembrin improves cardiac function and reduces remodeling in a rat model of post-infarct heart failure via the Nrf2/HO-1 antioxidant pathway.
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May support preclinical testing of pinocembrin in post-infarct HF; leaves open translation to human therapy.
Chen et al. (2021) studied Post-infarct heart failure (n=56). Pinocembrin vs. Saline was evaluated on Left ventricular ejection fraction (LVEF) at 8 weeks (p=<0.01). Pinocembrin significantly improved left ventricular ejection fraction to 54.91% compared to 43.83% with saline (p<0.01) and ameliorated cardiac remodeling in a rat model of post-infarct heart failure.
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