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April 28, 2026Autophagy

Exploiting autophagy-targeting natural compounds for potential antimicrobial actions

Seungwha Paik Soohyun Um In Soo Kim Eun-Jin Park Kyung Tae Kim Joyoti Basu Dong‐Chan Oh Eun-Kyeong Jo

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Key Points

Evaluate the antimicrobial effects of natural compounds that target autophagy pathways.
Utilized various autophagy-regulating natural compounds.
Investigated their effects on mitochondrial ROS and immune responses.
Analyzed the role of key transcription factors and signaling pathways.
Natural compounds significantly reduced levels of reactive oxygen species (ROS) in tested models.
Inhibition of neutrophil extracellular traps (NET) formation was observed with certain compounds.
Promoted activation of autophagy-related genes and pathways.

Implication

Demonstrates antimicrobial potential of natural compounds in autophagy modulation, suggesting a novel therapeutic approach.

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Cite This Study

Paik et al. (2026) studied this question.

synapsesocial.com/papers/69f4427a967e944ac5565fc9 https://doi.org/10.1080/15548627.2026.2662426

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