BACKGROUND/AIM: Natural killer (NK) cell-derived exosomes have demonstrated anti-cancer activity against various cancers, but the role in regulating ferroptosis in lung cancer remains unclear. This study investigates whether exosomes derived from NK-92 cells (NK92-exo) can trigger ferroptosis in A549 cells and elucidates the underlying mechanisms, providing a novel strategy for lung cancer treatment. MATERIALS AND METHODS: in A549 cells, and the expression levels of GPX4, NRF2, and PTGS2 were analyzed. RESULTS: overexpression significantly enhanced ferroptosis in A549 cells, an effect that was further enhanced by NK92-exo treatment. CONCLUSION: expression, thereby promoting ferroptosis in A549 cells. These findings suggest that NK92-exo may serve as a novel therapeutic bioproduct for lung cancer treatment.
Dong et al. (Fri,) studied this question.