From Normal Mucosa to Colorectal Cancer in Lynch Syndrome: Single-Cell Dissection of Cellular Heterogeneity and Communication Networks.

Key Points

• The aim is to create a single-cell atlas of colorectal cancer development in Lynch syndrome, focusing on cellular reprogramming and communication pathways.
• Single-cell analysis was conducted to assess cellular heterogeneity.
• Cell-cell communication networks were inferred using Cell Chat.
• Macrophages exhibit an immunosuppressive and pro-tumorigenic microenvironment.
• Epithelial remodeling and immune dysregulation were identified as potential therapeutic targets.