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Synapse
May 1, 20261 citations

An exceptionally conductive hydrogel for all-organic, ultraflexible, and chronic neural interfaces.

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RZRuiqi ZhuZHZhengwei HuZLZirui Lou

Key Points

  • This research aims to develop a hydrogel that maintains structural integrity for chronic neural interfaces while minimizing immune responses.
  • Developed an in-plane swelling control strategy with dry protective etching.
  • Created an all-organic electrocorticography (ECoG) array conforming to the cortical surface.
  • Assessed the hydrogel's performance by measuring signal quality over 550 days.
  • The hydrogel demonstrated exceptional signal quality during recordings.
  • Long-term recordings reached up to 550 days, indicating durability and functionality.
  • The design minimized foreign body response, enhancing compatibility with neural tissue.

Abstract

. We further developed an in-plane swelling control with a dry, soft-protective etching strategy that preserves the structural integrity during hydrogel processing. The resulting all-organic ECoG array conforms to the cortical surface, minimizing foreign body response and providing exceptional signal quality, with the longest record up to 550 d.

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Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/69f4427a967e944ac5566129https://doi.org/10.1073/pnas.2532840123
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