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May 1, 2026Leukemia & lymphoma/Leukemia and lymphoma0 citations

Radiotherapy may be omitted in children and adolescents with classical Hodgkin lymphoma in complete remission after frontline risk and response-adapted chemotherapy: a multicenter clinical trial (LH-GALOP 2017)

EAElizabeth Alfaro MSMagdalena Schelotto HZH M Zamaro

Key Points

To determine if radiotherapy can be safely omitted in children and adolescents with classical Hodgkin lymphoma who achieved complete remission after chemotherapy.
Multicenter clinical trial involving children and adolescents with classical Hodgkin lymphoma
Patients were stratified by risk (low, intermediate, high) after frontline chemotherapy
Follow-up duration averaged 58 months.
At 5 years, event-free survival (EFS) was 88.5% (SE = 3%)
Overall survival (OS) was 100%
Radiotherapy was delivered to 19.3% of patients, primarily in cases of partial remission or relapse.

Abstract

= 3-16.8) years. Low risk = 18%, Intermediate risk = 30%, High risk = 51%. CR after chemotherapy was obtained in 94 patients (86.2%). Radiotherapy was delivered in 19.3% of patients, including cases in partial remission, relapse, and refractory disease. With a median follow up of 58 months, at 5 years, EFSp was 88.5% (SE = 3%) and OS, 100%.

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