What question did this study set out to answer?

The aim is to develop topical formulations using oleuropein for optimized delivery in wound and burn treatment.

May 1, 20260 citations

Development and Enhanced Stability of an Oleuropein-Loaded Topical Formulation for Modified Delivery and Potential Use for Wound and Burn Therapy.

AGAylin Deljavan Ghodratı TCTansel Comoglu DKDogay Kinaci

Key Points

The aim is to develop topical formulations using oleuropein for optimized delivery in wound and burn treatment.
Formulated three semi-solid types: ointment, cream, and gel with oleuropein concentrations of 1%, 2.5%, and 5%.
Performed physicochemical characterization including pH, rheology, and drug content.
Evaluated effect on stability, release behavior, and dermal compatibility.
Ointment (F1) exhibited superior dermal compatibility and stability compared to other formulations.
Release behavior was optimal in the gel formulation (F3), improving therapeutic performance.

Abstract

This study aimed to develop and evaluate semi-solid topical formulations containing oleuropein, a phenolic compound with strong antioxidant and anti-inflammatory activity, for wound and burn treatment. The primary hypothesis was that optimizing formulation type would improve oleuropein stability, release behavior, and dermal compatibility, thereby enhancing therapeutic performance. Oleuropein isolated from olive leaves was incorporated into ointment (F1), cream (F2), and gel (F3) formulations at 1%, 2.5%, and 5%. Physicochemical characterization included pH, rheology, drug content, and

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