via their peroxidase- and catalase-like activities, generating cytotoxic ·OH while alleviating hypoxia to enhance IR808-mediated PDT. Under 808 nm laser irradiation, the system demonstrates combined photothermal and augmented photodynamic effects, leading to potent tumor ablation and robust ICD induction. Comprehensive evaluations revealed that this nanozyme system not only exhibits remarkable tumor suppression through multimodal therapy but also effectively activates systemic antitumor immunity both in vitro and in vivo. Furthermore, the platform enables precise cancer diagnosis through dual-modality magnetic resonance and near-infrared imaging capabilities. This study presents a novel paradigm for enhancing ICD and establishes a versatile theranostic strategy for pancreatic cancer treatment.
Jin et al. (Wed,) studied this question.