Shows that vancomycin impairs antifungal immunity in macrophages, indicating potential consequences for infection treatment.
yeast. Vancomycin-induced defects in fungal killing were associated with changes to mitochondria in antibiotic-exposed macrophages, which also exhibited enhanced oxidative stress and reduced survival during fungal infection. This work identifies a direct mechanism by which antibiotics may impair antifungal immunity.
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Bojang et al. (2026) studied this question.
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