Key result
Echocardiographic AT/ET ratio identifies severe aortic stenosis with ~97% diagnostic accuracy.
Why the study?
Accurate diagnosis of aortic stenosis severity is crucial for effective treatment, and the study aimed to define cutoff values for aortic ejection dynamic parameters in patients with severe AS.
Do echocardiographic aortic ejection dynamic parameters accurately diagnose severe aortic stenosis when compared to standard guidelines?
Case-Control (n=60)
No
Do echocardiographic aortic ejection dynamic parameters accurately diagnose severe aortic stenosis when compared to standard guidelines?
Effect estimate: AUC 0.967 (95% CI 0.9-1)
p-value: p=<0.001
Aortic ejection dynamic parameters, specifically an acceleration time cutoff of 73 ms, provide simple and highly accurate adjunctive echocardiographic metrics for diagnosing severe aortic stenosis.
AT/ET ratio may aid severe AS diagnosis; leaves open prospective validation before clinical adoption.
Background: Accurate diagnosis of aortic stenosis (AS) severity is crucial for effective treatment. This study aimed to define cutoff values for aortic ejection dynamic parameters, including ejection time (ET), acceleration time (AT), and the AT/ET ratio in patients with severe AS. Methods: and MPG ≥ 40 mmHg. Clinical data were recorded, and 2D and Doppler echocardiography, including ejection dynamic parameters were analyzed. Results: AT with a cutoff of 73 ms demonstrated perfect accuracy in diagnosing severe AS, with both sensitivity and specificity of 100%. ET with a cutoff of 278 ms showed 90% sensitivity and 100% specificity for identifying severe AS. Additionally, the AT/ET ratio exhibited a positive relationship with MPG (r = 0.55, P = 0.001) and a negative relationship with AVA (r = -0.52, P = 0.003). The AT/ET ratio, using a cutoff value of 0.278, yielded a sensitivity of 96% and a specificity of 100% for diagnosing severe AS. Conclusion: Aortic Doppler ejection dynamic parameters can serve as complementary assessment indices, diagnosing severe AS with acceptable accuracy.
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Aghajankhah et al. (2026) conducted a case-control in Severe Aortic Stenosis (n=60). Aortic ejection dynamic parameters (AT, ET, AT/ET ratio) vs. Controls without aortic stenosis was evaluated on Diagnostic accuracy of the acceleration time to ejection time (AT/ET) ratio for severe aortic stenosis (AUC 0.967, 95% CI 0.9-1, p=<0.001). An acceleration time to ejection time (AT/ET) ratio cutoff of 0.278 accurately diagnosed severe aortic stenosis with 96% sensitivity, 100% specificity, and an AUC of 0.967.
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