The Development of Chemical Probes for Targeting Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitors.

As a transcriptional coactivator and associated arginine methyltransferase 1, CARM1 controls various biological functions. CARM1 was thought to be a prospective therapeutic target, as anomalous appearance of the gene has been linked to the development of several cancer types. Since there aren't any CARM1 inhibitors available for use in clinical trials at the moment, Kindle is interested in the development of human pharmacological treatments that target CARM1. To confirm this PRMT as a therapeutic target, selective inhibitors of CARM1 would be helpful tools. In this review, we discuss the identification, description, and biological use of CARM1 inhibitors, focusing on significant developments in the field.