Phytochemical-mediated green synthesis of selenium nanoparticles using Catharanthus roseus and their physicochemical characterization, biological evaluation, and molecular docking analysis.

Key Points

• This work aims to explore the green synthesis of selenium nanoparticles using C. roseus and assess their bioactivity and interactions.
• Synthesis of selenium nanoparticles using phytochemicals from C. roseus.
• Physicochemical characterization of the nanoparticles.
• Molecular docking analysis for interaction studies.
• Selenium nanoparticles exhibited promising bioactivity at a concentration of 1.5 µg/mL.
• Stable interactions were observed between selenium-phytochemical complexes and biological targets during molecular docking.
• Findings establish a foundation for therapeutic development and future in vivo studies.