What question did this study set out to answer?

To quantify deep surgical site infection rates in open tibial shaft fractures treated with intramedullary nailing based on Gustilo-Anderson classification.

May 1, 2026

Infection Rate by Gustilo-Anderson Classification in Open Tibial Shaft Fractures Treated with an Intramedullary Nail - A Meta-Analysis.

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Authors

JSJanse SchermerhornUniversity of Maryland, Baltimore PMPatrick J McGloneWalter Reed National Military Medical Center ATArissa M. TorrieUniversity of Maryland, Baltimore

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Implication

Meta-analysis quantifies surgical site infection rates in tibial fractures treated with intramedullary nailing, suggesting higher rates with increased injury severity.

Key Points

To quantify deep surgical site infection rates in open tibial shaft fractures treated with intramedullary nailing based on Gustilo-Anderson classification.
Systematic review of MEDLINE, Embase, and Scopus for studies from January 2000 to May 2025.
Included studies reported deep surgical site infection rates by Gustilo-Anderson type in patients with open tibial shaft fractures treated with locked intramedullary nailing.
A single-arm meta-analysis estimated pooled infection rates using both fixed-effects and random-effects models.
Overall pooled deep surgical site infection rate was 13.2% (95% CI, 11.8 to 14.8%).
Infection rates varied by Gustilo-Anderson type: 6.2% for type I, 7.6% for type II, 11.9% for type IIIA, 25.0% for type IIIB, and 41.8% for type IIIC fractures.
Significant heterogeneity in infection rates across classifications (Q = 104.85, df = 4, P < 0.001), particularly in type IIIB fractures (I2 = 50.7%).

Cite This Study

Schermerhorn et al. (2026) studied this question.

synapsesocial.com/papers/69f44325967e944ac556677d https://doi.org/10.1097/bot.0000000000003199

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Implication

Meta-analysis quantifies surgical site infection rates in tibial fractures treated with intramedullary nailing, suggesting higher rates with increased injury severity.

Infection Rate by Gustilo-Anderson Classification in Open Tibial Shaft Fractures Treated with an Intramedullary Nail - A Meta-Analysis.

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Cite This Study

Infection Rate by Gustilo-Anderson Classification in Open Tibial Shaft Fractures Treated with an Intramedullary Nail - A Meta-Analysis.

Discussion

Member takes

Implication

Key Points

Cite This Study

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