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May 1, 2026

Assessment of cytotoxicity and genomic instability induced by coal-derived nanoparticles in V79 and HaCaT Cells.

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Authors

AMAlvaro Miranda-GuevaraWMWilner Martínez-LópezGLGrethel León-Mejía

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Overview

Randomized trial evaluates cytotoxic and genotoxic effects of coal-derived nanoparticles in cell lines, suggesting health risks.

Key Points

  • This study aims to evaluate the cytotoxic and genotoxic effects of coal-derived nanoparticles on V79 and HaCaT cell lines.
  • Coal-derived nanoparticles were isolated using an acid-based separation method.
  • Cells were exposed to nanoparticles at concentrations of 50, 150, and 300 μg/mL.
  • Cytotoxicity and genotoxicity were assessed using various assays, including comet and micronucleus tests.
  • Coal-derived nanoparticles induced a dose-dependent increase in genomic instability and cell mortality.
  • Higher concentrations of nanoparticles led to increased apoptosis in both V79 and HaCaT cell lines.
  • Significant morphological changes were observed in cells exposed to coal nanoparticles.

Cite This Study

Miranda-Guevara et al. (2026) studied this question.

synapsesocial.com/papers/69f44325967e944ac55667behttps://doi.org/10.1007/s00204-026-04316-z
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