Antagonistic Effect of Erythropoietin Receptor Signaling in Macrophages and Type II Alveolar Epithelial Cells on Pulmonary Fibrosis in Mice.

BACKGROUND/AIM: Although stimulation of erythropoietin receptor (EPOR) signaling demonstrates cytoprotective effects-including anti-apoptosis, pro-proliferation, and promotion of inflammation resolution-in various disease models, its alterations and specific role in the process of pulmonary fibrosis are still not well understood. The study aimed at investigating the changes of lung EPOR signal in pulmonary fibrosis and the effect of different cell EPOR signal on pulmonary fibrosis. MATERIALS AND METHODS: ) knockout mice were used to assess fibrosis severity. RESULTS: mice displayed exacerbated fibrosis. CONCLUSION: EPOR signaling in macrophages and type II alveolar epithelial cells exerts opposing effects on pulmonary fibrosis, with targeted activation EPOR signaling in alveolar epithelial cells representing a potential therapeutic strategy.